The next generation of autologous regeneration.
Biological PRF Filler is the evolution of PRP and represents one of the most advanced and natural rejuvenation treatments in aesthetic medicine.
PRF stands for Platelet-Rich Fibrin. It is a 100% natural, biocompatible biological material derived from your own blood that promotes tissue repair and regeneration. It is considered one of the most effective anti-aging treatments, as it enhances firmness, improves skin texture, and smooths wrinkles.
PRF is more than just a cosmetic treatment; it is a premier tool of Regenerative Medicine. Being 100% autologous and biocompatible, it is derived exclusively from your own blood. Through a specialized centrifugation process, a three-dimensional fibrin matrix is created, trapping platelets, leukocytes, and stem cells.
This matrix acts as a 100% natural biological implant that:
Activates fibroblasts for the production of collagen and elastin.
Improves skin quality, texture, and firmness.
Gradually releases growth factors such as VEGF, TGF-β, and EGF.
Promotes angiogenesis (creation of new blood vessels).
Known as a “Bio-Filler,” it offers subtle volume while simultaneously regenerating the skin’s structure from within. Unlike synthetic fillers that simply “fill” a space, PRF transforms the skin’s quality over time. Its biological action is long-lasting, enhancing skin health for months following the application.
PRF is the most advanced form of autologous therapy available. It is entirely safe, with zero risk of allergic reactions since it is derived from your own blood.
It is highly effective for the face, neck, and décolletage. Notably, it is an ideal treatment for the under-eye area, where few safe and reliable alternatives exist. It is also an excellent option for treating acne scars.
Whether used alone or in combination with treatments like Microneedling, Radiofrequency (RF), or Fractional Laser, it provides scientifically proven results that lead to true skin regeneration.
“PRF is an innovative tool of regenerative medicine. It creates a 3D fibrin matrix that releases growth factors like VEGF, TGF-β, and EGF, stimulating collagen, elastin, and angiogenesis. It is not a permanent filler, but a treatment that transforms the skin from within. For those seeking both volume and regeneration, we apply specialized hybrid PRF protocols.”
The biological action is long-lasting, as it improves skin quality for months. The immediate volume provided by the fibrin matrix lasts about 1–2 weeks. However, by performing a series of 3 sessions, the “stacking” effect increases both the volume capacity and the overall duration of the result.
Yes. Dr. Drakotos creates specialized, 100% personalized protocols. Combining PRF with Hyaluronic Acid (HA) fillers creates a “Smart Filler”—HA provides stable, immediate volume, while PRF enhances biological regeneration and skin texture.
These hybrid protocols offer the best of both worlds. Hyaluronic Acid provides a stable fill that lasts for months, while PRF provides the biological “boost” needed for regeneration, better texture, and a more natural-looking outcome.